Abstract
A kinetic analysis of the inhibition of malt alpha-amylase by compounds based on ascorbic acid has shown the mode of inhibition to be competitive for the parent compound, but more complex for its derivatives. We have further simplified the ascorbic acid ene-diol pharmacophore by demonstrating that dihydroxyfumaric acid is also a good inhibitor of malt alpha-amylase.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Ascorbic Acid / analogs & derivatives*
-
Ascorbic Acid / chemical synthesis*
-
Ascorbic Acid / chemistry
-
Ascorbic Acid / pharmacology
-
Edible Grain / enzymology
-
Enzyme Inhibitors / chemical synthesis*
-
Enzyme Inhibitors / chemistry
-
Enzyme Inhibitors / pharmacology
-
Kinetics
-
Molecular Structure
-
Structure-Activity Relationship
-
alpha-Amylases / antagonists & inhibitors*
Substances
-
Enzyme Inhibitors
-
alpha-Amylases
-
Ascorbic Acid